San Fierro commonly experiences rainstorms. The city's infrastructure and buildings are not visibly damaged from the earthquake, the only such damage being in the Doherty area. The freeway section does not seem to have any visible connection to the existing freeway, however. The most obvious sign of the intense damage is the crumbled section of freeway lying to the immediate west of Garver Bridge's San Fierro approach, which is an apparent emulation of the damage done to San Francisco's Embarcadero Freeway or even the Cypress Street Viaduct in Oakland, California, whose remnants could be seen for years after the earthquake. The city bears visible scars of an earthquake, a likely reference to the Loma Prieta Earthquake of 1989. Furthermore, in a crude reference to anal sex, the city's baseball team, the San Fierro Packers, is sponsored by none other than Fierro Fudge. San Fierro is also home to the football team, the San Fierro 69ers, a double entendre referring to both the San Francisco 49ers and the ' 69' sexual position. In addition to this, San Fierro has a district marked by rainbow signs that is meant to emulate San Francisco's famous Castro District, home to a sizeable homosexual population. There is a sizeable country club complete with a golf course within San Fierro. The name derives from the motto for the city of San Francisco, ' Oro en Paz, Fierro en guerra', Spanish for 'Gold in Peace, Iron in War'. Supposedly of Spanish foundation like San Francisco, Fierro is old Spanish for Hierro (Iron), not a likely name for a saint.

San Fierro is connected to Los Santos and Las Venturas by road, rail and air. San Fierro is a moderately sized city with the beautiful San Fierro Bay (based on San Francisco Bay) to the northeast and The Panopticon to the east. To the north of the city, across the Gant Bridge (a re-creation of the famous Golden Gate Bridge), lies the town of Bayside, and northeast of the city lies the county of Tierra Robada. South of the city lies the massive Mount Chiliad (based on Mount Diablo) and the small town of Angel Pine in Whetstone. It is the most urbanized city, and is situated on a peninsula on the western part of the state. San Fierro has a majority Asian population and is very diverse, economically and ethnically. San Fierro is the second largest city in population and smallest in area in San Andreas.

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